Introduction to research programmes

Dendrimers used as transfection agents
Biomaterials are being developed in response to clinical needs. Research includes work on new biomaterials for drug release, transfection, prosthetics and enhanced implant biocompatibility. Engineered surfaces and scaffolds are being developed for cell culture and tissue engineering.

Tissue engineering of skin - photograph of a skin patch grown in the laboratory.
Tissue engineering research at Sheffield is working towards a number of targets including of cartilage, nerve, bone, cornea, skin, urethra and oral muscosa. These are important for clinical applications, as well as providing proof-of-concept for engineering more complex tissues.

Photograph of a microfluidic device.
Devices, implants & bioreactors devices for dignity, prosthetics and implants.

Cell culture reactor.
Stem cells for bone, nerve, tendon, gene and therapeutics applications.

False colour of an osteoblast on a bone substitute.
Imaging and analysis techniques used at Sheffield to analyse and evaluate engineered tissues, implant materials and prosthetics.

Mathematical model of drug delivery to the lung
Computational systems biology takes data from cell biology and body imaging techniques to model prosthetic tissues and design heart valves and drug delivery systems. Increasingly it is also important for following complex interactions, such as signalling pathways within and between cells, and helping us to understand how tissues develop, and how best to engineer them for clinical use.

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